Kukoamine A
Kukoamine A
CAS: 75288-96-9
Molecular Formula: C28H42N4O6
Kukoamine A - Names and Identifiers
| Name | Kukoamine A |
| Synonyms | NSC 5398 kukoamine A Kukoamine A 1,14-Bis(dihydrocaffeoyl)spermidine N1,N12-Bis(dihydrocaffeoyl) spermine N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide] N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide] Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy- N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide) |
| CAS | 75288-96-9 |
Kukoamine A - Physico-chemical Properties
| Molecular Formula | C28H42N4O6 |
| Molar Mass | 530.66 |
| Density | 1.213±0.06 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 872.1±65.0 °C(Predicted) |
| Solubility | Easily soluble in water, partially soluble in methanol. |
| Appearance | White crystalline powder |
| pKa | 9.48±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD29904538 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the bone skin. |
Kukoamine A - Reference
| Reference Show more | 1. Yossa Nzeuwa, Irma Belinda, et al. "Comparison of the origin and phenolic contents of Lycium ruthenicum Murr. by high‐performance liquid chromatography fingerprinting combined with quadrupole time‐of‐flight mass spectrometry and chemometrics." Journal of s 2. [IF=3.645] Irma Belinda Yossa Nzeuwa et al."Comparison of the origin and phenolic contents of Lycium ruthenicum Murr. by high-performance liquid chromatography fingerprinting combined with quadrupole time-of-flight mass spectrometry and chemometrics."J Sep Sci. 2017 3. [IF=1.381] Yuping Li et al."Variation of Kukoamine A (KuA) and B (KuB) contents and related meteorological factors for Cortex Lycii radicis of different areas."Biochem Syst Ecol. 2020 Feb;88:103985 |
Kukoamine A - Reference Information
| effect | diguetin is a kind of alkaloids isolated from digupi, which has significant hypotensive effect. lycii cortex is the dried root bark of Lycium barbarum. Early spring or autumn after the roots, Wash, peel the root bark, dry, for hot flashes of Yin deficiency, bone steaming and night sweats, lung heat Cough, hemoptysis, internal heat diabetes and other diseases. Modern pharmacological studies have shown that it has lowering blood pressure, lowering blood sugar, regulating blood lipids, antipyretic, antibacterial and antiviral activities. |
| preparation | , the flow rate is 1-4ml/min/g raw material, and methanol is introduced as entrainer at the same time. The flow rate is 1-4ml/min/g, the extraction temperature of raw material is 40-50 ℃, the pressure is 15-30mpa, and the extraction time is 1-3h,|
| biological activity | Kukoamine A is A natural derivative of spermine, which is an effective Trypanosoma thiophosphate reductase. Inhibitor, Ki = 1.8 μm. It has antihypertensive activity. |
| Target | Ki: 1.8 μm |
| Use | for content determination/identification/pharmacological experiments |
Last Update：2024-04-09 20:52:54
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Kukoamine A
METHYL E-2,3-DIMETHYLACRYLATE
2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-
2-叠氮-1-(3-氟-苯基)乙酮
Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester, trans-
5-氨基-N-甲基-1-苯并噻吩-2-甲酰胺
2-AMINO-1-(2-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL
橙黄决明素-6-葡萄糖苷
Terbium chloride
METHYL E-2,3-DIMETHYLACRYLATE
2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-
2-叠氮-1-(3-氟-苯基)乙酮
Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-, methyl ester, trans-
5-氨基-N-甲基-1-苯并噻吩-2-甲酰胺
2-AMINO-1-(2-TRIFLUOROMETHYL-PHENYL)-ETHANOL HCL
橙黄决明素-6-葡萄糖苷
Terbium chloride